We are lucky in NZ that as far as morphine sulphate is concerned the protocol is relatively open. Titrate 2mg-5mg boluses IV every 3-5 minutes with no upper dose limit (it would be 40mg's as that's all we carry). Paed's have a per kilo IV dosage, adults 10mb IM and kids 0.2mg/kg IM...although there is a dinstinct focus on IV. Contra's/Precautions: * No IM in the "shocked" patient or ? MI patient (apparently modifies some enzyme returns * Hypersensitivity * For severe pain not responding to Entonox * Not to be used to facilitate airway establishment * GCS > 10 * Caution with hypotensive pts Would tend to agree with some of the comments here about caution in IV incremental doses. My experience in administering to a wide range of people suggests start small, then build consistent with the patients pain, their response to the morphine, physiological changes and overall effectiveness. Sometimes morphine does little e.g. burns, other times it aggravates the base condition e.g. bilary colic. Have fun playing the the new Rx. I presume Nubain is a gonna?